CHI3L1

CHI3L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HJV, 1HJW, 1HJX, 1NWR, 1NWS, 1NWT, 1NWU
Identifiers
Aliases	CHI3L1, chitinase 3-like 1 (cartilage glycoprotein-39), ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39, chitinase 3 like 1, YK-40
External IDs	OMIM: 601525; MGI: 1340899; HomoloGene: 55569; GeneCards: CHI3L1; OMA:CHI3L1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,186,704 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,190,181 bp
RNA expression pattern
	Top expressed in
	pericardium; ; cartilage tissue; ; skin of thigh; ; vulva; ; glomerulus; ; inferior olivary nucleus; ; metanephric glomerulus; ; external globus pallidus; ; internal globus pallidus; ; bone marrow;
	Top expressed in
	granulocyte; ; right lung lobe; ; retinal pigment epithelium; ; tibiofemoral joint; ; left lung; ; ciliary body; ; lactiferous gland; ; lumbar subsegment of spinal cord; ; left lung lobe; ; blood;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	chitinase activity; extracellular matrix structural constituent; chitin binding; carbohydrate binding; protein binding;
Cellular component	endoplasmic reticulum; perinuclear region of cytoplasm; extracellular exosome; extracellular region; extracellular space; specific granule lumen; cytoplasm; extracellular matrix;
Biological process	positive regulation of protein kinase B signaling; response to interleukin-1; response to interleukin-6; lung development; cellular response to tumor necrosis factor; response to mechanical stimulus; activation of NF-kappaB-inducing kinase activity; positive regulation of angiogenesis; response to tumor necrosis factor; cartilage development; positive regulation of peptidyl-threonine phosphorylation; cellular response to interleukin-1; positive regulation of ERK1 and ERK2 cascade; inflammatory response; apoptotic process; neutrophil degranulation; chitin catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1116
	12654
	ENSG00000133048
	ENSMUSG00000064246
	P36222
	Q61362
	NM_001276
	NM_007695; NM_001374626
	NP_001267; NP_001267.2
	NP_031721; NP_001361555
	Wikidata
View/Edit Human	View/Edit Mouse

Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass. YKL-40 is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells, vascular smooth muscle cells, and hepatic stellate cells. The biological function of YKL-40 is unclear. It is not known to have a specific receptor. Its pattern of expression is associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas and asthma.