CHL1

CHL1
Identifiers
Aliases	CHL1, CALL, L1CAM2, cell adhesion molecule L1 like
External IDs	OMIM: 607416; MGI: 1098266; HomoloGene: 21314; GeneCards: CHL1; OMA:CHL1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	409,417 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	103,727,172 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; superior frontal gyrus; ; sural nerve; ; spinal ganglia; ; postcentral gyrus; ; frontal pole; ; Brodmann area 10; ; trigeminal ganglion; ; middle temporal gyrus;
	Top expressed in
	spermatid; ; subiculum; ; ventral tegmental area; ; lobe of cerebellum; ; lateral hypothalamus; ; dorsomedial hypothalamic nucleus; ; supraoptic nucleus; ; substantia nigra; ; cerebellar vermis; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protease binding;
Cellular component	integral component of membrane; membrane; plasma membrane; apical part of cell; extracellular region; dendrite; extracellular exosome;
Biological process	negative regulation of neuron apoptotic process; cell differentiation; cognition; axon regeneration; adult locomotory behavior; neuron migration; nervous system development; multicellular organism development; cell adhesion; exploration behavior; neuron projection development; signal transduction; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	10752
	12661
	ENSG00000134121
	ENSMUSG00000030077
	O00533
	P70232
	NM_001253387; NM_001253388; NM_006614
	NM_007697
	NP_001240316; NP_001240317; NP_006605
	NP_031723
	Wikidata
View/Edit Human	View/Edit Mouse

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.

CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF, and can act as a helicase protein during the interphase stage of mitosis.

The protein, however, has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.