Muscarinic acetylcholine receptor M5

CHRM5
Identifiers
Aliases	CHRM5, HM5, cholinergic receptor muscarinic 5
External IDs	OMIM: 118496; MGI: 109248; HomoloGene: 22697; GeneCards: CHRM5; OMA:CHRM5 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	34,067,458 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	112,311,114 bp
RNA expression pattern
	Top expressed in
	testicle; ; corpus callosum; ; C1 segment; ; gonad; ; substantia nigra; ; Hypothalamus; ; inferior ganglion of vagus nerve; ; placenta; ; prefrontal cortex; ; right lobe of liver;
	Top expressed in
	ventromedial nucleus; ; mammillary body; ; subiculum; ; ventral tegmental area; ; lateral hypothalamus; ; Amygdala; ; anterior amygdaloid area; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylinositol phospholipase C activity; G protein-coupled acetylcholine receptor activity; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; dendrite;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; regulation of phosphatidylinositol dephosphorylation; gastric acid secretion; transmission of nerve impulse; synaptic transmission, cholinergic; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; dopamine transport; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; cell population proliferation; signal transduction; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1133
	213788
	ENSG00000184984
	ENSMUSG00000074939
	P08912
	Q920H4
	NM_012125; NM_001320917
	NM_205783
	NP_001307846; NP_036257
	NP_991352
	Wikidata
View/Edit Human	View/Edit Mouse

The human muscarinic acetylcholine receptor M₅, encoded by the CHRM5 gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins. It is coupled to G_q protein. Binding of the endogenous ligand acetylcholine to the M₅ receptor triggers a number of cellular responses such as adenylate cyclase inhibition, phosphoinositide degradation, and potassium channel modulation. Muscarinic receptors mediate many of the effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to effectively decrease cyclic AMP levels and downregulate the activity of protein kinase A (PKA).