CHRNA1

CHRNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZJS
Identifiers
Aliases	CHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit
External IDs	OMIM: 100690; MGI: 87885; HomoloGene: 59; GeneCards: CHRNA1; OMA:CHRNA1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	174,787,935 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	73,410,682 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; glutes; ; tibialis anterior muscle; ; deltoid muscle; ; muscle of thigh; ; testicle; ; triceps brachii muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	ankle; ; extraocular muscle; ; ankle joint; ; internal carotid artery; ; soleus muscle; ; vastus lateralis muscle; ; temporal muscle; ; triceps brachii muscle; ; thoracic diaphragm; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	extracellular ligand-gated ion channel activity; acetylcholine receptor activity; ligand-gated ion channel activity; ion channel activity; acetylcholine binding; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; membrane; synapse; cell junction; plasma membrane; neuromuscular junction; cell surface; postsynaptic membrane; acetylcholine-gated channel complex; integral component of postsynaptic specialization membrane; integral component of plasma membrane; neuron projection;
Biological process	muscle cell cellular homeostasis; neuron cellular homeostasis; regulation of membrane potential; skeletal muscle contraction; response to nicotine; cation transport; synaptic transmission, cholinergic; ion transport; skeletal muscle tissue growth; neuromuscular synaptic transmission; neuromuscular process; neuromuscular junction development; musculoskeletal movement; signal transduction; neuronal action potential; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; ion transmembrane transport; chemical synaptic transmission; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	1134
	11435
	ENSG00000138435
	ENSMUSG00000027107
	P02708
	P04756
	NM_001039523; NM_000079
	NM_007389
	NP_000070; NP_001034612
	NP_031415
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.