CHRNE

CHRNE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DF9
Identifiers
Aliases	CHRNE, ACHRE, CMS1D, CMS1E, CMS2A, FCCMS, SCCMS, CMS4A, CMS4B, CMS4C, cholinergic receptor nicotinic epsilon subunit
External IDs	OMIM: 100725; MGI: 87894; HomoloGene: 60; GeneCards: CHRNE; OMA:CHRNE - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,934,438 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,510,042 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; anterior pituitary; ; cardiac muscle tissue of right atrium; ; granulocyte; ; testicle; ; right lobe of liver; ; skin of leg; ; body of pancreas; ; stromal cell of endometrium; ; blood;
	Top expressed in
	spermatid; ; spermatocyte; ; extraocular muscle; ; seminiferous tubule; ; muscle of thigh; ; ankle; ; embryo; ; quadriceps femoris muscle; ; lip; ; muscle of leg;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine binding; cation transmembrane transporter activity; acetylcholine receptor activity; ion channel activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; acetylcholine-gated channel complex; neuromuscular junction; integral component of postsynaptic specialization membrane; neuron projection;
Biological process	muscle contraction; regulation of membrane potential; response to nicotine; synaptic transmission, cholinergic; ion transport; cation transmembrane transport; neuromuscular synaptic transmission; signal transduction; ion transmembrane transport; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; chemical synaptic transmission; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	1145
	11448
	ENSG00000108556
	ENSMUSG00000014609
	Q04844
	P20782
	NM_000080
	NM_009603
	NP_000071
	NP_033733
	Wikidata
View/Edit Human	View/Edit Mouse

Acetylcholine receptor subunit epsilon is a protein that in humans is encoded by the CHRNE gene.

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.