CHSY1

CHSY1
Identifiers
Aliases	CHSY1, CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1
External IDs	OMIM: 608183; MGI: 2681120; HomoloGene: 8950; GeneCards: CHSY1; OMA:CHSY1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,252,048 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,823,546 bp
RNA expression pattern
	Top expressed in
	tibia; ; decidua; ; visceral pleura; ; endothelial cell; ; Epithelium of choroid plexus; ; vena cava; ; hair follicle; ; cartilage tissue; ; gingival epithelium; ; synovial joint;
	Top expressed in
	hand; ; secondary oocyte; ; Gonadal ridge; ; primary oocyte; ; endocardial cushion; ; semi-lunar valve; ; renal corpuscle; ; aortic valve; ; calvaria; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; transferase activity; acetylgalactosaminyltransferase activity; glycosyltransferase activity; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;
Cellular component	extracellular region; integral component of membrane; Golgi apparatus; Golgi membrane; Golgi cisterna membrane; membrane;
Biological process	proximal/distal pattern formation; bone morphogenesis; cartilage development; chondrocyte development; negative regulation of ossification; sulfation; positive regulation of smoothened signaling pathway; response to nutrient levels; chondroitin sulfate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	22856
	269941
	ENSG00000131873
	ENSMUSG00000032640
	Q86X52
	Q6ZQ11
	NM_014918
	NM_001081163
	NP_055733
	NP_001074632
	Wikidata
View/Edit Human	View/Edit Mouse

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.