CHUK

CHUK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BRT
Identifiers
Aliases	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, conserved helix-loop-helix ubiquitous kinase, component of inhibitor of nuclear factor kappa B kinase complex, BPS2
External IDs	OMIM: 600664; MGI: 99484; HomoloGene: 979; GeneCards: CHUK; OMA:CHUK - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,229,596 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,095,919 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; middle frontal gyrus; ; Brodmann area 10; ; islet of Langerhans; ; palpebral conjunctiva; ; germinal epithelium; ; gingival epithelium; ; monocyte; ; gonad; ; Achilles tendon;
	Top expressed in
	neural layer of retina; ; right kidney; ; seminal vesicula; ; proximal tubule; ; jejunum; ; human kidney; ; liver; ; epithelium of small intestine; ; intestinal villus; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; IkappaB kinase activity; nucleotide binding; protein homodimerization activity; scaffold protein binding; kinase activity; protein serine/threonine kinase activity; protein binding; protein heterodimerization activity; ATP binding; identical protein binding;
Cellular component	intracellular membrane-bounded organelle; nucleoplasm; CD40 receptor complex; cytoplasmic side of plasma membrane; IkappaB kinase complex; nucleus; cytoplasm; cytosol;
Biological process	response to amino acid; phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; skeletal muscle contraction; anatomical structure morphogenesis; response to virus; cellular response to tumor necrosis factor; stimulatory C-type lectin receptor signaling pathway; response to hydroperoxide; response to organic substance; TRIF-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; protein phosphorylation; response to lipopolysaccharide; positive regulation of NF-kappaB transcription factor activity; stress-activated MAPK cascade; response to acetate; immune response; Rho protein signal transduction; positive regulation of I-kappaB kinase/NF-kappaB signaling; striated muscle cell differentiation; innate immune response; inflammatory response; T cell receptor signaling pathway; response to toxic substance; positive regulation of transcription by RNA polymerase II; I-kappaB phosphorylation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; peptidyl-serine phosphorylation; tumor necrosis factor-mediated signaling pathway; I-kappaB kinase/NF-kappaB signaling; cellular response to reactive oxygen species; NIK/NF-kappaB signaling; positive regulation of transcription, DNA-templated; cellular response to cadmium ion; cellular response to virus; negative regulation of NF-kappaB transcription factor activity; MyD88-independent toll-like receptor signaling pathway; interleukin-1-mediated signaling pathway; response to cholecystokinin;
	Sources:Amigo / QuickGO
Orthologs
	1147
	12675
	ENSG00000213341
	ENSMUSG00000025199
	O15111
	Q60680
	NM_001278; NM_001320928
	NM_001162410; NM_007700
	NP_001269; NP_001307857
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.