CIB1

CIB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DGU, 1DGV, 1XO5, 1Y1A, 2L4H, 2L4I, 2LM5
Identifiers
Aliases	CIB1, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, calcium and integrin binding 1
External IDs	OMIM: 602293; MGI: 1344418; HomoloGene: 4654; GeneCards: CIB1; OMA:CIB1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,234,047 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,882,561 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of transverse colon; ; right uterine tube; ; olfactory zone of nasal mucosa; ; body of pancreas; ; nasal epithelium; ; granulocyte; ; right adrenal gland; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	spermatocyte; ; spermatid; ; right kidney; ; duodenum; ; epithelium of stomach; ; yolk sac; ; pyloric antrum; ; jejunum; ; crypt of lieberkuhn of small intestine; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase inhibitor activity; calcium ion binding; protein-membrane adaptor activity; transmembrane transporter binding; metal ion binding; protein C-terminus binding; protein binding; calcium-dependent protein kinase inhibitor activity; protein kinase binding;
Cellular component	cytoplasm; vesicle; Golgi apparatus; cell projection; centrosome; membrane; growth cone; plasma membrane; nucleoplasm; microtubule organizing center; ruffle membrane; axon; filopodium tip; dendrite; soma; apical plasma membrane; endoplasmic reticulum; perinuclear region of cytoplasm; neuron projection; sarcolemma; extracellular exosome; cytoskeleton; nucleus; cell periphery; lamellipodium;
Biological process	negative regulation of protein phosphorylation; positive regulation of protein targeting to membrane; thrombopoietin-mediated signaling pathway; negative regulation of protein kinase B signaling; cell differentiation; cellular response to nerve growth factor stimulus; positive regulation of protein phosphorylation; negative regulation of neuron projection development; regulation of cell division; positive regulation of cell migration involved in sprouting angiogenesis; extrinsic apoptotic signaling pathway; positive regulation of cell-matrix adhesion; positive regulation of cell migration; cellular response to growth factor stimulus; cellular response to tumor necrosis factor; platelet formation; negative regulation of apoptotic process; negative regulation of megakaryocyte differentiation; positive regulation of protein serine/threonine kinase activity; positive regulation of calcineurin-NFAT signaling cascade; cell division; cellular response to DNA damage stimulus; negative regulation of microtubule depolymerization; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of cell growth; response to ischemia; cell adhesion; regulation of cell population proliferation; positive regulation of NF-kappaB transcription factor activity; double-strand break repair; angiogenesis; spermatogenesis; positive regulation of cell population proliferation; spermatid development; positive regulation of ERK1 and ERK2 cascade; cytoplasmic microtubule organization; endomitotic cell cycle; cell cycle; positive regulation of cell adhesion mediated by integrin; positive regulation of male germ cell proliferation; negative regulation of cell population proliferation; apoptotic process; positive regulation of catalytic activity; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10519
	23991
	ENSG00000185043
	ENSMUSG00000030538
	Q99828
	Q9Z0F4
	NM_001277764; NM_006384
	NM_001291275; NM_001291276; NM_011870
	NP_001264693; NP_006375
	NP_001278204; NP_001278205; NP_036000
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene and is located in Chromosome 15. The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end-joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).