Capicua (protein)

CIC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M41, 4J2J, 4J2L
Identifiers
Aliases	CIC, capicua transcriptional repressor, MRD45, CIC gene
External IDs	OMIM: 612082; MGI: 1918972; HomoloGene: 87637; GeneCards: CIC; OMA:CIC - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,295,797 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,993,584 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; olfactory bulb; ; sural nerve; ; beta cell; ; right testis; ; gastric mucosa; ; left testis; ; right ovary; ; body of uterus; ; anterior pituitary;
	Top expressed in
	cerebellar cortex; ; neural layer of retina; ; bone marrow; ; olfactory bulb; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; superior frontal gyrus; ; striatum of neuraxis; ; thymus; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; brain development; learning; memory; social behavior; negative regulation of transcription, DNA-templated; lung alveolus development;
	Sources:Amigo / QuickGO
Orthologs
	23152
	71722
	ENSG00000079432
	ENSMUSG00000005442
	Q96RK0
	Q924A2
NM_001304815; NM_015125; NM_001379480; NM_001379482; NM_001379484;
	NM_001379485; NM_001386298
	NM_001110131; NM_001110132; NM_027882; NM_001302811
NP_001291744; NP_055940; NP_001366409; NP_001366411; NP_001366413;
	NP_001366414
	NP_001289740; NP_082158
	Wikidata
View/Edit Human	View/Edit Mouse

Capicua transcriptional repressor is a protein that in humans is encoded by the CIC gene. Capicua functions as a transcriptional repressor in a way that ensures its impact on the progression of cancer, and plays a significant role in the operation of the central nervous system through its interaction with ataxin 1. The name of the protein derives from the Catalan expression cap-i-cua which literally translates to "head-and-tail".