CIDEA

CIDEA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EEL
Identifiers
Aliases	CIDEA, CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a
External IDs	OMIM: 604440; MGI: 1270845; HomoloGene: 77852; GeneCards: CIDEA; OMA:CIDEA - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	12,277,595 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	67,500,855 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; subcutaneous adipose tissue; ; skin of thigh; ; vulva; ; synovial joint; ; skin of arm; ; skin of abdomen; ; human penis; ; prefrontal cortex; ; pericardium;
	Top expressed in
	tunica adventitia of aorta; ; intercostal muscle; ; skin of external ear; ; parotid gland; ; lip; ; tunica media of zone of aorta; ; mammary gland; ; subcutaneous adipose tissue; ; trachea; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity;
Cellular component	cytoplasm; lipid droplet; intracellular anatomical structure; mitochondrion; mitochondrial envelope; nucleus; cytosol;
Biological process	regulation of apoptotic process; negative regulation of execution phase of apoptosis; regulation of transcription, DNA-templated; lipid metabolism; lipid storage; cell death; negative regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-templated; positive regulation of sequestering of triglyceride; response to stilbenoid; negative regulation of tumor necrosis factor production; temperature homeostasis; negative regulation of lipid catabolic process; regulation of apoptotic DNA fragmentation; apoptotic process; lipid droplet organization; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1149
	12683
	ENSG00000176194
	ENSMUSG00000024526
	O60543
	O70302
	NM_001279; NM_001318383
	NM_007702
	NP_001270; NP_001305312
	NP_031728
	Wikidata
View/Edit Human	View/Edit Mouse

Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.