CIRBP

CIRBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5S
Identifiers
Aliases	CIRBP, CIRP, cold inducible RNA binding protein
External IDs	OMIM: 602649; MGI: 893588; HomoloGene: 980; GeneCards: CIRBP; OMA:CIRBP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,274,880 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,172,786 bp
RNA expression pattern
	Top expressed in
	tibia; ; corpus epididymis; ; caput epididymis; ; parietal pleura; ; germinal epithelium; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; middle temporal gyrus; ; left ovary;
	Top expressed in
	neural layer of retina; ; lip; ; cerebellar cortex; ; molar; ; ventricular zone; ; spermatocyte; ; superior frontal gyrus; ; primary visual cortex; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation repressor activity; nucleic acid binding; protein binding; small ribosomal subunit rRNA binding; mRNA 3'-UTR binding; RNA binding; poly(U) RNA binding;
Cellular component	cytoplasm; cytoplasmic stress granule; nucleolus; nucleus; nucleoplasm; spliceosomal complex; ribonucleoprotein complex;
Biological process	stress granule assembly; response to cold; mRNA stabilization; response to UV; positive regulation of translation; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	1153
	12696
	ENSG00000099622
	ENSMUSG00000045193
	Q14011; Q53XX5
	P60824
	NM_001280; NM_001300815; NM_001300829
	NM_007705
	NP_001271; NP_001287744; NP_001287758; NP_001271.1
NP_031731; NP_001366350; NP_001366351; NP_001366352; NP_001366353;
	NP_001366354
	Wikidata
View/Edit Human	View/Edit Mouse

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene. The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia.