CLCNKB

CLCNKB
Identifiers
Aliases	CLCNKB, CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb
External IDs	OMIM: 602023; MGI: 1329026; HomoloGene: 65; GeneCards: CLCNKB; OMA:CLCNKB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,057,311 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,126,035 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; parotid gland; ; sperm; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; human kidney; ; apex of heart; ; oocyte; ; cerebellar hemisphere; ; right hemisphere of cerebellum;
	Top expressed in
	right kidney; ; distal tubule; ; outer renal medulla; ; human kidney; ; connecting tubule; ; Ascending limb of loop of Henle; ; stria vascularis; ; inner renal medulla; ; inner stripe of outer renal medulla; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; voltage-gated ion channel activity; chloride channel activity; voltage-gated chloride channel activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; chloride channel complex; membrane;
Biological process	ion transmembrane transport; chloride transport; excretion; regulation of ion transmembrane transport; ion transport; transmembrane transport; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1188
	12733
	ENSG00000184908
	ENSMUSG00000033770
	P51801
	Q9WUB7
	NM_000085; NM_001165945
	NM_001146307; NM_024412
	NP_000076; NP_001159417
	NP_001139779; NP_077723
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.

Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome. CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.