CLDN18

CLDN18
Identifiers
Aliases	CLDN18, SFTA5, SFTPJ, claudin 18
External IDs	OMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	138,033,655 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	99,599,320 bp
RNA expression pattern
	Top expressed in
	pylorus; ; lower lobe of lung; ; cardia; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; body of stomach; ; gastric mucosa; ; visceral pleura; ; fundus;
	Top expressed in
	mucous cell of stomach; ; right lung lobe; ; epithelium of stomach; ; pyloric antrum; ; left lung; ; left lung lobe; ; blastocyst; ; duodenum; ; embryo; ; right kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; identical protein binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; membrane; bicellular tight junction;
Biological process	negative regulation of protein localization to nucleus; TNFSF11-mediated signaling pathway; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; digestive tract development; negative regulation of osteoclast development; negative regulation of bone resorption; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	51208
	56492
	ENSG00000066405
	ENSMUSG00000032473
	P56856
	P56857
	NM_016369; NM_001002026
	NM_001194921; NM_001194922; NM_001194923; NM_019815
	NP_001002026; NP_057453
	NP_001181850; NP_001181851; NP_001181852; NP_062789
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . [supplied by OMIM]