CLDN7

CLDN7
Identifiers
Aliases	CLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDs	OMIM: 609131; MGI: 1859285; HomoloGene: 9649; GeneCards: CLDN7; OMA:CLDN7 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,263,983 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,858,711 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; rectum; ; right uterine tube; ; olfactory zone of nasal mucosa; ; minor salivary glands; ; body of pancreas; ; left lobe of thyroid gland; ; islet of Langerhans; ; right lobe of thyroid gland;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; left colon; ; migratory enteric neural crest cell; ; ileum; ; duodenum; ; yolk sac; ; medullary collecting duct; ; jejunum; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; identical protein binding; protein binding; cell adhesion molecule binding;
Cellular component	bicellular tight junction; cell junction; basolateral plasma membrane; membrane; lateral plasma membrane; integral component of membrane; apicolateral plasma membrane; plasma membrane;
Biological process	negative regulation of protein homooligomerization; negative regulation of cell adhesion; positive regulation of cell motility; negative regulation of apoptotic process; positive regulation of cell population proliferation; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	1366
	53624
	ENSG00000181885; ENSG00000288292
	ENSMUSG00000018569
	O95471
	Q9Z261
	NM_001307; NM_001185022; NM_001185023
	NM_001193619; NM_016887
	NP_001171951; NP_001171952; NP_001298
	NP_001180548; NP_058583
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM]