CLEC6A

CLEC6A
Identifiers
Aliases	CLEC6A, CLEC4N, CLECSF10, C-type lectin domain family 6 member A, dectin-2, C-type lectin domain containing 6A, hDECTIN-2
External IDs	OMIM: 613579; MGI: 1861231; HomoloGene: 84615; GeneCards: CLEC6A; OMA:CLEC6A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,478,330 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	123,223,980 bp
RNA expression pattern
	Top expressed in
	testicle; ; monocyte; ; appendix; ; granulocyte; ; blood; ; lymph node; ; gonad; ; smooth muscle tissue; ; gallbladder; ; endometrium;
	Top expressed in
	stroma of bone marrow; ; spleen; ; calvaria; ; mesenteric lymph nodes; ; right lung lobe; ; granulocyte; ; thymus; ; carotid body; ; spermatid; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding; calcium ion binding; mannose binding; metal ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; stimulatory C-type lectin receptor signaling pathway; adaptive immune response; defense response to fungus; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	93978
	56620
	ENSG00000205846
	ENSMUSG00000023349
	Q6EIG7
	Q9JKF4
	NM_001007033; NM_001317999
	NM_001190320; NM_001190321; NM_020001
	NP_001007034; NP_001304928
	NP_001177249; NP_001177250; NP_064385
	Wikidata
View/Edit Human	View/Edit Mouse

Dectin-2 or C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein is a type II transmembrane protein with an extracellular carbohydrate recognition domain. It functions as a pattern recognition receptor recognizing α-mannans and as such plays an important role in innate immune response to fungi. Expression is found on macrophages and dendritic cells. It can also be found at low levels in Langerhans cells and peripheral blood monocytes, where expression levels could be increased upon induction of inflammation.

Dectin-2 genes are located in the telomeric region of the natural killer gene cluster on mouse chromosome 6 and human chromosome 12. The dectin-2 cluster is composed of genes encoding dectin-2, DCIR, DCAR, BDCA-2, Mincle and Clecsf8, which are the members of the group II C-type lectin family.