CLIC2

CLIC2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2PER, 2R4V, 2R5G
Identifiers
Aliases	CLIC2, CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2
External IDs	OMIM: 300138; HomoloGene: 48010; GeneCards: CLIC2; OMA:CLIC2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	155,334,657 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; right lung; ; spleen; ; upper lobe of left lung; ; gallbladder; ; superficial temporal artery; ; lymph node; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutathione transferase activity; voltage-gated ion channel activity; glutathione peroxidase activity; protein binding; chloride channel activity;
Cellular component	cytoplasm; integral component of membrane; membrane; intracellular anatomical structure; chloride channel complex; nucleus;
Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of ion transmembrane transport; ion transport; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of binding; chloride transport; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; signal transduction; cellular oxidant detoxification; glutathione metabolic process; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1193
	n/a
	ENSG00000155962
	n/a
	O15247
	n/a
	NM_001289
	n/a
	NP_001280
	n/a
	Wikidata
View/Edit Human

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.