CLIC6

CLIC6
Identifiers
Aliases	CLIC6, CLIC1L, chloride intracellular channel 6
External IDs	OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	34,718,227 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	92,338,131 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; bronchial epithelial cell; ; nasal epithelium; ; caput epididymis; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; mucosa of paranasal sinus; ; pancreatic epithelial cell; ; olfactory zone of nasal mucosa; ; pancreatic ductal cell;
	Top expressed in
	Epithelium of choroid plexus; ; epithelium of stomach; ; retinal pigment epithelium; ; olfactory epithelium; ; ciliary body; ; migratory enteric neural crest cell; ; epithelium of small intestine; ; yolk sac; ; left colon; ; efferent ductule;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated ion channel activity; glutathione transferase activity; chloride channel activity; D2 dopamine receptor binding; D3 dopamine receptor binding; D4 dopamine receptor binding;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane; chloride channel complex; nucleus; cytoplasm;
Biological process	regulation of ion transmembrane transport; chloride transport; ion transport; glutathione metabolic process; chloride transmembrane transport; transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54102
	209195
	ENSG00000159212
	ENSMUSG00000022949
	Q96NY7
	Q8BHB9
	NM_053277; NM_001317009
	NM_172469
	NP_001303938; NP_444507
	NP_766057
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.