CLK3 (gene)

CLK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EU9, 2EXE, 2WU6, 2WU7, 3RAW
Identifiers
Aliases	CLK3, PHPHCLK3/152, CDC like kinase 3
External IDs	OMIM: 602990; MGI: 1098670; HomoloGene: 101534; GeneCards: CLK3; OMA:CLK3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,645,414 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,673,143 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left testis; ; right testis; ; monocyte; ; anterior pituitary; ; left lobe of thyroid gland; ; mucosa of transverse colon; ; skin of leg; ; minor salivary glands; ; skin of abdomen;
	Top expressed in
	thymus; ; granulocyte; ; lip; ; muscle of thigh; ; aortic valve; ; ascending aorta; ; neural layer of retina; ; fetal liver hematopoietic progenitor cell; ; superior surface of tongue; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; identical protein binding; RNA binding;
Cellular component	cytoplasm; nuclear speck; membrane; nucleoplasm; acrosomal vesicle; intermediate filament cytoskeleton; cytoplasmic vesicle; nucleus;
Biological process	phosphorylation; protein phosphorylation; regulation of RNA splicing; protein autophosphorylation; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1198
	102414
	ENSG00000179335
	ENSMUSG00000032316
	P49761
	O35492
	NM_001130028; NM_001292; NM_003992
	NM_007713
	NP_001123500; NP_003983
	NP_031739
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.