CLOCK

CLOCK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H10
Identifiers
Aliases	CLOCK, KAT13D, bHLHe8, clock circadian regulator
External IDs	OMIM: 601851; MGI: 99698; HomoloGene: 3603; GeneCards: CLOCK; OMA:CLOCK - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	55,546,909 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	76,452,639 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; germinal epithelium; ; caput epididymis; ; tail of epididymis; ; retinal pigment epithelium; ; testicle; ; tibialis anterior muscle; ; tibia; ; gingival epithelium; ; lower lobe of lung;
	Top expressed in
	retinal pigment epithelium; ; zygote; ; ciliary body; ; secondary oocyte; ; epithelium of lens; ; conjunctival fornix; ; skin of external ear; ; left colon; ; aorta; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; histone acetyltransferase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; E-box binding; core promoter sequence-specific DNA binding; protein binding; chromatin DNA binding; acyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; chromatoid body; intracellular membrane-bounded organelle; transcription regulator complex; chromosome; nucleoplasm; nucleus; cytosol;
Biological process	negative regulation of glucocorticoid receptor signaling pathway; positive regulation of inflammatory response; regulation of transcription, DNA-templated; photoperiodism; regulation of insulin secretion; rhythmic process; regulation of transcription by RNA polymerase II; DNA damage checkpoint signaling; regulation of type B pancreatic cell development; transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; response to redox state; cellular response to DNA damage stimulus; positive regulation of NF-kappaB transcription factor activity; circadian rhythm; spermatogenesis; regulation of hair cycle; cellular response to ionizing radiation; negative regulation of transcription, DNA-templated; signal transduction; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; histone acetylation; protein acetylation; regulation of circadian rhythm;
	Sources:Amigo / QuickGO
Orthologs
	9575
	12753
	ENSG00000134852
	ENSMUSG00000029238
	O15516
	O08785
	NM_001267843; NM_004898
	NM_007715; NM_001289826; NM_001305222
	NP_001254772; NP_004889
	NP_001276755; NP_001292151; NP_031741
	Wikidata
View/Edit Human	View/Edit Mouse

CLOCK (backronym for circadian locomotor output cycles kaput) is a gene encoding a basic helix-loop-helix-PAS transcription factor that is known to affect both the persistence and period of circadian rhythms.

Research shows that the CLOCK gene plays a major role as an activator of downstream elements in the pathway critical to the generation of circadian rhythms.