ATP-dependent Clp protease proteolytic subunit

CLPP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TG6
Identifiers
Aliases	CLPP, PRLTS3, DFNB81, caseinolytic mitochondrial matrix peptidase proteolytic subunit
External IDs	OMIM: 601119; MGI: 1858213; HomoloGene: 4385; GeneCards: CLPP; OMA:CLPP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,370,242 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,303,188 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; mucosa of transverse colon; ; apex of heart; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; left adrenal cortex; ; body of stomach;
	Top expressed in
	interventricular septum; ; right kidney; ; facial motor nucleus; ; morula; ; morula; ; condyle; ; blastocyst; ; right ventricle; ; adrenal gland; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; protein binding; hydrolase activity; identical protein binding; ATP-dependent peptidase activity; ATPase binding;
Cellular component	mitochondrial matrix; mitochondrion; endopeptidase Clp complex;
Biological process	proteolysis involved in cellular protein catabolic process; protein homooligomerization; proteolysis; protein quality control for misfolded or incompletely synthesized proteins;
	Sources:Amigo / QuickGO
Orthologs
	8192
	53895
	ENSG00000125656
	ENSMUSG00000002660
	Q16740
	O88696
	NM_006012
	NM_017393
	NP_006003
	NP_059089
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent Clp protease proteolytic subunit (ClpP) is an enzyme that in humans is encoded by the CLPP gene. This protein is an essential component to form the protein complex of Clp protease (Endopeptidase Clp).