CLTC

CLTC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XZG, 4G55
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
External IDs	OMIM: 118955; MGI: 2388633; HomoloGene: 3572; GeneCards: CLTC; OMA:CLTC - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	59,696,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	86,648,391 bp
RNA expression pattern
	Top expressed in
	Pons; ; lateral nuclear group of thalamus; ; Brodmann area 46; ; middle temporal gyrus; ; mucosa of sigmoid colon; ; orbitofrontal cortex; ; postcentral gyrus; ; corpus epididymis; ; trabecular bone; ; pars compacta;
	Top expressed in
	stroma of bone marrow; ; habenula; ; pontine nuclei; ; medial geniculate nucleus; ; medial dorsal nucleus; ; medial vestibular nucleus; ; dorsomedial hypothalamic nucleus; ; lateral geniculate nucleus; ; deep cerebellar nuclei; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; double-stranded RNA binding; protein kinase binding; structural molecule activity; RNA binding; clathrin light chain binding; disordered domain specific binding; low-density lipoprotein particle receptor binding; ubiquitin-specific protease binding;
Cellular component	extracellular vesicle; cytosol; clathrin-coated endocytic vesicle membrane; clathrin coat of coated pit; trans-Golgi network membrane; clathrin coat of trans-Golgi network vesicle; focal adhesion; melanosome; plasma membrane; endolysosome membrane; clathrin-coated pit; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; clathrin-coated vesicle; extracellular matrix; membrane; mitotic spindle microtubule; cytoplasm; lysosome; endosome; spindle; cytoskeleton; clathrin coat; clathrin complex; protein-containing complex; intracellular membrane-bounded organelle; clathrin-coated endocytic vesicle; mitotic spindle; intracellular anatomical structure;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; receptor internalization; negative regulation of protein localization to plasma membrane; retrograde transport, endosome to Golgi; osteoblast differentiation; vesicle-mediated transport; negative regulation of hyaluronan biosynthetic process; intracellular protein transport; Wnt signaling pathway, planar cell polarity pathway; regulation of mitotic spindle organization; autophagy; microtubule-based movement; cell cycle; cell division; membrane organization; mitotic cell cycle; receptor-mediated endocytosis; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; clathrin coat assembly; clathrin-dependent endocytosis; amyloid-beta clearance by transcytosis;
	Sources:Amigo / QuickGO
Orthologs
	1213
	67300
	ENSG00000141367
	ENSMUSG00000047126
	Q00610
	Q68FD5
	NM_001288653; NM_004859
	NM_001003908; NM_001356393
	NP_001275582; NP_004850
	NP_001003908; NP_001343322
	Wikidata
View/Edit Human	View/Edit Mouse

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.