CMKLR1

CMKLR1
Identifiers
Aliases	CMKLR1, CHEMERINR, ChemR23, DEZ, RVER1, chemerin chemokine-like receptor 1, CCX832
External IDs	OMIM: 602351; MGI: 109603; HomoloGene: 129967; GeneCards: CMKLR1; OMA:CMKLR1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	108,339,317 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	113,788,487 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; Descending thoracic aorta; ; Achilles tendon; ; tendon of biceps brachii; ; ascending aorta; ; granulocyte; ; spleen; ; left coronary artery; ; monocyte; ; tibial arteries;
	Top expressed in
	zygote; ; secondary oocyte; ; white adipose tissue; ; primary oocyte; ; subcutaneous adipose tissue; ; tail of embryo; ; internal carotid artery; ; mesenteric lymph nodes; ; stroma of bone marrow; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; chemokine receptor activity; signal transducer activity; signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	chemotaxis; skeletal system development; G protein-coupled receptor signaling pathway; positive regulation of macrophage chemotaxis; negative regulation of NF-kappaB transcription factor activity; positive regulation of fat cell differentiation; immune response; regulation of calcium-mediated signaling; signal transduction; negative regulation of interleukin-12 production; chemokine-mediated signaling pathway; complement receptor mediated signaling pathway; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1240
	14747
	ENSG00000174600
	ENSMUSG00000042190
	Q99788
	P97468
	NM_004072; NM_001142343; NM_001142344; NM_001142345
	NM_008153; NM_001359060
	NP_001135815; NP_001135816; NP_001135817; NP_004063
	NP_032179; NP_001345989
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine like receptor 1 also known as ChemR23 (Chemerin Receptor 23) is a protein that in humans is encoded by the CMKLR1 gene. Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omega-3 fatty acid eicosapentaenoic acid-derived specialized pro-resolving molecule, resolvin E1 (see Specialized proresolving mediators#EPA-derived resolvins (i.e. RvE)). The murine receptor that shares almost 80% homology with the human receptor, is called Dez.