CNOT1

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CCR4-Not complex component, Not1
CCR4-Not complex component, Not1
Identifiers
Symbol	Not1
Pfam	PF04054
InterPro	IPR007196
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

CNOT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0D, 4CQO, 4CRV, 4CRW, 4CT4, 4CT6, 4CT7, 4GMJ, 4GML, 4J8S, 5ANR, 5FU6, 5FU7
Identifiers
Aliases	CNOT1, CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12, VIBOS
External IDs	OMIM: 604917; MGI: 2442402; HomoloGene: 9453; GeneCards: CNOT1; OMA:CNOT1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	58,629,885 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	96,534,092 bp
RNA expression pattern
	Top expressed in
	gonad; ; left testis; ; right testis; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; granulocyte; ; epithelium of colon;
	Top expressed in
	tail of embryo; ; genital tubercle; ; spermatocyte; ; ventricular zone; ; spermatid; ; yolk sac; ; neural layer of retina; ; zygote; ; granulocyte; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; protein domain specific binding; protein binding; retinoic acid receptor binding; armadillo repeat domain binding; molecular adaptor activity; estrogen receptor binding; RNA binding;
Cellular component	membrane; CCR4-NOT complex; peroxisomal membrane; P-body; CCR4-NOT core complex; nucleus; extracellular space; cytoplasm; cytosol;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of transcription, DNA-templated; negative regulation of retinoic acid receptor signaling pathway; regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; positive regulation of mRNA catabolic process; transcription, DNA-templated; multicellular organism development; positive regulation of cytoplasmic mRNA processing body assembly; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; gene silencing by miRNA; gene silencing; negative regulation of intracellular estrogen receptor signaling pathway; regulation of translation; RNA phosphodiester bond hydrolysis, exonucleolytic; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	23019
	234594
	ENSG00000125107
	ENSMUSG00000036550
	A5YKK6; H3BNB1
	Q6ZQ08
	NM_001265612; NM_016284; NM_206999
	NM_001205226; NM_153164; NM_178078; NM_001372351; NM_001372353
	NP_001252541; NP_057368; NP_996882
	NP_001192155; NP_694804; NP_835179; NP_001359280; NP_001359282
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.

It is a part of the CCR4-Not complex, which deadenylates mRNAs. CNOT1 acts as a scaffold protein, binding other subunits of the complex.