CNOT2

CNOT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0D, 4C0F, 5FU6, 5FU7
Identifiers
Aliases	CNOT2, CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS
External IDs	OMIM: 604909; MGI: 1919318; HomoloGene: 40953; GeneCards: CNOT2; OMA:CNOT2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	70,354,993 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	116,417,416 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; Achilles tendon; ; nipple; ; epithelium of nasopharynx; ; human penis; ; epithelium of colon; ; ganglionic eminence; ; skin of abdomen; ; cerebellar cortex;
	Top expressed in
	genital tubercle; ; ciliary body; ; internal carotid artery; ; external carotid artery; ; medullary collecting duct; ; iris; ; tail of embryo; ; primitive streak; ; retinal pigment epithelium; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; transcription coregulator activity; protein binding;
Cellular component	cytoplasm; membrane; CCR4-NOT complex; P-body; CCR4-NOT core complex; nucleus; cytosol; plasma membrane;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; positive regulation of cytoplasmic mRNA processing body assembly; trophectodermal cell differentiation; gene silencing; negative regulation of intracellular estrogen receptor signaling pathway; regulation of translation; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	4848
	72068
	ENSG00000111596
	ENSMUSG00000020166
	Q9NZN8
	Q8C5L3
	NM_001199302; NM_001199303; NM_014515
NM_001037846; NM_001037847; NM_001037848; NM_028082; NM_001359247;
	NM_001359248; NM_001359249; NM_001359250; NM_001359251; NM_001359252; NM_001359253; NM_001359563
	NP_001186231; NP_001186232; NP_055330
NP_001032935; NP_001032936; NP_001032937; NP_082358; NP_001346176;
	NP_001346177; NP_001346178; NP_001346179; NP_001346180; NP_001346181; NP_001346182; NP_001346492
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. It is a subunit of the CCR4-Not deadenylase complex.