CNOT6

CNOT6
Identifiers
Aliases	CNOT6, CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6
External IDs	OMIM: 608951; MGI: 2144529; HomoloGene: 69187; GeneCards: CNOT6; OMA:CNOT6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	180,578,358 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	49,603,550 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; cerebellar vermis; ; ganglionic eminence; ; ventricular zone; ; retinal pigment epithelium; ; epithelium of nasopharynx; ; trabecular bone; ; amniotic fluid; ; bronchial epithelial cell;
	Top expressed in
	retinal pigment epithelium; ; saccule; ; otic vesicle; ; ciliary body; ; ureter; ; medial ganglionic eminence; ; cumulus cell; ; superior cervical ganglion; ; trigeminal ganglion; ; otic placode;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; exoribonuclease activity; metal ion binding; protein binding; RNA binding; nuclease activity; exonuclease activity; hydrolase activity; 3'-5'-exoribonuclease activity;
Cellular component	cytoplasm; cytosol; membrane; CCR4-NOT complex; nucleus;
Biological process	regulation of transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; transcription, DNA-templated; positive regulation of cytoplasmic mRNA processing body assembly; gene silencing by miRNA; positive regulation of cell population proliferation; exonucleolytic catabolism of deadenylated mRNA; gene silencing; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of translation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA poly(A) tail shortening;
	Sources:Amigo / QuickGO
Orthologs
	57472
	104625
	ENSG00000113300
	ENSMUSG00000020362
	Q9ULM6
	Q8K3P5
	NM_001303241; NM_015455; NM_001370472; NM_001370473; NM_001370474
	NM_001290741; NM_212484; NM_001363356; NM_001363357
	NP_001290170; NP_001357401; NP_001357402; NP_001357403
	NP_001277670; NP_997649; NP_001350285; NP_001350286
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.

The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates.