CNO (gene)

BLOC1S4
Identifiers
Aliases	BLOC1S4, BCAS4L, BLOS4, CNO, biogenesis of lysosomal organelles complex 1 subunit 4
External IDs	OMIM: 605695; MGI: 1929230; HomoloGene: 10155; GeneCards: BLOC1S4; OMA:BLOC1S4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	6,717,664 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	36,905,994 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; granulocyte; ; gonad; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; monocyte; ; cartilage tissue; ; left adrenal gland; ; left adrenal cortex; ; right adrenal gland;
	Top expressed in
	fossa; ; ciliary body; ; retinal pigment epithelium; ; condyle; ; conjunctival fornix; ; interventricular septum; ; iris; ; Epithelium of choroid plexus; ; epithelium of lens; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; BLOC-1 complex; axon cytoplasm;
Biological process	anterograde axonal transport; melanosome organization; intracellular transport; anterograde synaptic vesicle transport; neuron projection development; platelet aggregation; neuromuscular process controlling balance;
	Sources:Amigo / QuickGO
Orthologs
	55330
	117197
	ENSG00000186222
	ENSMUSG00000060708
	Q9NUP1
	Q8VED2
	NM_018366
	NM_133724
	NP_060836
	NP_598485
	Wikidata
View/Edit Human	View/Edit Mouse

Protein cappuccino homolog is a protein that in humans is encoded by the CNO gene.

This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky–Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking.