CNTRL

CNTRL
Identifiers
Aliases	CNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs	OMIM: 605496; MGI: 1889576; HomoloGene: 38260; GeneCards: CNTRL; OMA:CNTRL - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	121,177,729 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	35,178,822 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; ventricular zone; ; bronchial epithelial cell; ; testicle; ; left testis; ; right testis; ; sural nerve; ; sperm; ; monocyte;
	Top expressed in
	genital tubercle; ; ventricular zone; ; granulocyte; ; spermatocyte; ; tail of embryo; ; thymus; ; mesenteric lymph nodes; ; spermatid; ; spleen; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein tyrosine kinase activity; cytoskeletal protein binding;
Cellular component	microtubule organizing center; centrosome; cytoskeleton; membrane; cytoplasm; cytosol; midbody; Flemming body; centriolar subdistal appendage;
Biological process	cell division; cell cycle; G2/M transition of mitotic cell cycle; peptidyl-tyrosine phosphorylation; mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; regulation of cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	11064
	26920
	ENSG00000119397
	ENSMUSG00000057110
	Q7Z7A1
	A2AL36
NM_007018; NM_001330762; NM_001369892; NM_001369893; NM_001369894;
	NM_001369895; NM_001369896
	NM_001290635; NM_012018; NM_030000; NM_001379274; NM_001379275
NP_001317691; NP_008949; NP_001356821; NP_001356822; NP_001356823;
	NP_001356824; NP_001356825
	NP_001277564; NP_036148; NP_001366203; NP_001366204
	Wikidata
View/Edit Human	View/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.