COG2

COG2
Identifiers
Aliases	COG2, LDLC, component of oligomeric golgi complex 2, CDG2Q
External IDs	OMIM: 606974; MGI: 1923582; HomoloGene: 7206; GeneCards: COG2; OMA:COG2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	230,693,982 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	125,278,747 bp
RNA expression pattern
	Top expressed in
	rectum; ; right hemisphere of cerebellum; ; right adrenal cortex; ; pancreatic ductal cell; ; islet of Langerhans; ; gonad; ; left adrenal gland; ; left adrenal cortex; ; granulocyte; ; tibialis anterior muscle;
	Top expressed in
	yolk sac; ; lens; ; granulocyte; ; spermatocyte; ; right kidney; ; neural layer of retina; ; epithelium of stomach; ; muscle of thigh; ; proximal tubule; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein-containing complex binding;
Cellular component	Golgi transport complex; cytosol; Golgi membrane; Golgi stack; Golgi apparatus; membrane; trans-Golgi network membrane;
Biological process	protein transport; endoplasmic reticulum to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; Golgi organization;
	Sources:Amigo / QuickGO
Orthologs
	22796
	76332
	ENSG00000135775
	ENSMUSG00000031979
	Q14746
	Q921L5
	NM_007357; NM_001145036
	NM_029746
	NP_001138508; NP_031383
	NP_084022
	Wikidata
View/Edit Human	View/Edit Mouse

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).