Collagen, type XXV, alpha 1

COL25A1
Identifiers
Aliases	COL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDs	OMIM: 610004; MGI: 1924268; HomoloGene: 57111; GeneCards: COL25A1; OMA:COL25A1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	109,302,752 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	130,393,526 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; jejunal mucosa; ; buccal mucosa cell; ; testicle; ; Achilles tendon; ; subcutaneous adipose tissue; ; anterior pituitary; ; sural nerve;
	Top expressed in
	median eminence; ; lateral septal nucleus; ; medial dorsal nucleus; ; arcuate nucleus; ; substantia nigra; ; habenula; ; superior colliculus; ; lateral geniculate nucleus; ; anterior amygdaloid area; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparin binding; amyloid-beta binding; extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength;
Cellular component	integral component of membrane; extracellular region; plasma membrane; collagen; endoplasmic reticulum lumen; membrane; extracellular space; integral component of plasma membrane; extracellular matrix; collagen-containing extracellular matrix;
Biological process	axonogenesis involved in innervation; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	84570
	77018
	ENSG00000188517
	ENSMUSG00000058897
	Q9BXS0
	Q99MQ5
	NM_001256074; NM_032518; NM_198721
	NM_001244952; NM_029838; NM_198711
	NP_001243003; NP_115907; NP_942014
	NP_001231881; NP_084114; NP_942004
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM]