Collagen, type XXVII, alpha 1

COL27A1
Identifiers
Aliases	COL27A1, STLS, collagen type XXVII alpha 1, collagen type XXVII alpha 1 chain
External IDs	OMIM: 608461; MGI: 2672118; HomoloGene: 69400; GeneCards: COL27A1; OMA:COL27A1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,312,511 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,334,991 bp
RNA expression pattern
	Top expressed in
	tibia; ; cerebellar vermis; ; pancreatic ductal cell; ; canal of the cervix; ; pylorus; ; cartilage tissue; ; cerebellar hemisphere; ; renal medulla; ; right hemisphere of cerebellum; ; skin of arm;
	Top expressed in
	molar; ; lesser wing of sphenoid bone; ; stria vascularis; ; otolith organ; ; utricle; ; internal carotid artery; ; hand; ; index finger; ; phalanx of index finger; ; rib;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent; metal ion binding; extracellular matrix structural constituent conferring tensile strength;
Cellular component	extracellular region; fibrillar collagen trimer; collagen; endoplasmic reticulum lumen; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	growth plate cartilage chondrocyte development; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	85301
	373864
	ENSG00000196739
	ENSMUSG00000045672
	Q8IZC6
	Q5QNQ9
	NM_032161; NM_032888
	NM_025685
	NP_116277
	NP_079961
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene.

COL27A1 is a type XXVII collagen. It was discovered by James Pace. This gene appears to be turned on in cartilage, the eye, and in the ear. Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton.

Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form major structural elements in extracellular matrices of cartilage, skin, and tendon.