Collagen, type VIII, alpha 1

COL8A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O91
Identifiers
Aliases	COL8A1, C3orf7, collagen type VIII alpha 1, collagen type VIII alpha 1 chain
External IDs	OMIM: 120251; MGI: 88463; HomoloGene: 22423; GeneCards: COL8A1; OMA:COL8A1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	99,799,226 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	57,575,100 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; retinal pigment epithelium; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; sural nerve; ; parietal pleura; ; germinal epithelium; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	pineal gland; ; retinal pigment epithelium; ; calvaria; ; vestibular membrane of cochlear duct; ; Epithelium of choroid plexus; ; choroid plexus of fourth ventricle; ; skin of external ear; ; body of femur; ; stroma of bone marrow; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength;
Cellular component	extracellular matrix; basement membrane; collagen type VIII trimer; collagen; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; collagen-containing extracellular matrix;
Biological process	collagen catabolic process; cell adhesion; extracellular matrix organization; epithelial cell proliferation; endodermal cell differentiation; camera-type eye morphogenesis; angiogenesis; positive regulation of cell-substrate adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1295
	12837
	ENSG00000144810
	ENSMUSG00000068196
	P27658
	Q00780
	NM_001850; NM_020351
	NM_007739
	NP_001841; NP_065084
	NP_031765
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed.