COPS2

COPS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	COPS2, ALIEN, CSN2, SGN2, TRIP15, COP9 signalosome subunit 2
External IDs	OMIM: 604508; MGI: 1330276; HomoloGene: 134283; GeneCards: COPS2; OMA:COPS2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	49,155,661 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	125,701,059 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; thoracic diaphragm; ; Achilles tendon; ; parietal pleura; ; gingival epithelium; ; tail of epididymis; ; glutes; ; amniotic fluid; ; corpus epididymis; ; germinal epithelium;
	Top expressed in
	otic placode; ; saccule; ; tail of embryo; ; genital tubercle; ; otic vesicle; ; mandibular prominence; ; maxillary prominence; ; abdominal wall; ; cumulus cell; ; somite;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; transcription corepressor activity;
Cellular component	nucleoplasm; nucleus; COP9 signalosome; cytoplasm; cytosol;
Biological process	negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; nucleotide-excision repair, DNA damage recognition; neuron differentiation; cell population proliferation; signal transduction; negative regulation of nucleic acid-templated transcription; skeletal muscle cell differentiation; transcription-coupled nucleotide-excision repair; neurogenesis; negative regulation of transcription, DNA-templated; protein deneddylation; post-translational protein modification; protein phosphorylation; inner cell mass cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9318
	12848
	ENSG00000166200
	ENSMUSG00000027206
	P61201
	P61202
	NM_004236; NM_001143887
	NM_001285507; NM_001285512; NM_001285513; NM_009939
	NP_001137359; NP_004227
	NP_001272436; NP_001272441; NP_001272442; NP_034069
	Wikidata
View/Edit Human	View/Edit Mouse

COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene. It encodes a subunit of the COP9 signalosome.