COP9 signalosome complex subunit 3

COPS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	COPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDs	OMIM: 604665; MGI: 1349409; HomoloGene: 2710; GeneCards: COPS3; OMA:COPS3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	17,281,273 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	59,839,838 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; gonad; ; muscle of thigh; ; ganglionic eminence; ; right testis; ; left testis; ; skeletal muscle tissue; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; muscle of arm;
	Top expressed in
	spermatocyte; ; facial motor nucleus; ; medial ganglionic eminence; ; spermatid; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; intercostal muscle; ; primitive streak; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	COP9 signalosome; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	transcription-coupled nucleotide-excision repair; in utero embryonic development; ubiquitin-dependent protein catabolic process; nucleotide-excision repair, DNA damage recognition; signal transduction; response to light stimulus; protein deneddylation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	8533
	26572
	ENSG00000141030
	ENSMUSG00000019373
	Q9UNS2
	O88543
NM_001199125; NM_003653; NM_001316354; NM_001316355; NM_001316356;
	NM_001316357; NM_001316358
	NM_011991
NP_001186054; NP_001303283; NP_001303284; NP_001303285; NP_001303286;
	NP_001303287; NP_003644
	NP_036121
	Wikidata
View/Edit Human	View/Edit Mouse

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene. It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.