COP9 constitutive photomorphogenic homolog subunit 5

COPS5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4F7O, 4WSN
Identifiers
Aliases	COPS5, CSN5, JAB1, MOV-34, SGN5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome subunit 5
External IDs	OMIM: 604850; MGI: 1349415; HomoloGene: 55992; GeneCards: COPS5; OMA:COPS5 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	67,083,783 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	10,108,393 bp
RNA expression pattern
	Top expressed in
	sperm; ; right ventricle; ; myocardium of left ventricle; ; gastrocnemius muscle; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; right testis; ; left testis;
	Top expressed in
	genital tubercle; ; tail of embryo; ; medial ganglionic eminence; ; facial motor nucleus; ; temporal muscle; ; ventricular zone; ; lens; ; muscle of thigh; ; triceps brachii muscle; ; seminiferous tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; transcription coactivator activity; metal ion binding; peptidase activity; protein binding; thiol-dependent deubiquitinase; hydrolase activity; metallopeptidase activity; NEDD8-specific protease activity; enzyme binding; macrophage migration inhibitory factor binding; metalloendopeptidase activity;
Cellular component	cytoplasm; eukaryotic translation initiation factor 3 complex; synaptic vesicle; synapse; nucleoplasm; cell junction; perinuclear region of cytoplasm; COP9 signalosome; cytoplasmic vesicle; nucleus; chromatin; cytosol;
Biological process	protein biosynthesis; nucleotide-excision repair, DNA damage recognition; transcription by RNA polymerase II; proteolysis; regulation of cell cycle; protein deubiquitination; regulation of JNK cascade; exosomal secretion; transcription-coupled nucleotide-excision repair; regulation of IRE1-mediated unfolded protein response; positive regulation of transcription by RNA polymerase II; translational initiation; protein deneddylation; post-translational protein modification; negative regulation of apoptotic process; positive regulation of DNA-binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	10987
	26754
	ENSG00000121022
	ENSMUSG00000025917
	Q92905
	O35864
	NM_006837
	NM_001277101; NM_013715
	NP_006828; NP_006828.2
	NP_001264030; NP_038743
	Wikidata
View/Edit Human	View/Edit Mouse

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.