COQ2

COQ2
Identifiers
Aliases	COQ2, CL640, COQ10D1, MSA1, PHB:PPT, coenzyme Q2, polyprenyltransferase
External IDs	OMIM: 609825; MGI: 1919133; HomoloGene: 69192; GeneCards: COQ2; OMA:COQ2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	83,284,914 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	100,823,006 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; gingival epithelium; ; vastus lateralis muscle; ; monocyte; ; body of tongue; ; triceps brachii muscle; ; muscle of thigh; ; glutes; ; deltoid muscle;
	Top expressed in
	left ventricle; ; interventricular septum; ; proximal tubule; ; quadriceps femoris muscle; ; right kidney; ; muscle of thigh; ; upper arm; ; neural layer of retina; ; muscle tissue; ; visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; 4-hydroxybenzoate nonaprenyltransferase activity; prenyltransferase activity; 4-hydroxybenzoate decaprenyltransferase activity; transferase activity, transferring alkyl or aryl (other than methyl) groups;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; integral component of mitochondrial inner membrane;
Biological process	glycerol metabolic process; isoprenoid biosynthetic process; ubiquinone biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	27235
	71883
	ENSG00000173085
	ENSMUSG00000029319
	Q96H96
	Q66JT7
	NM_015697; NM_001358921
	NM_027978
	NP_056512; NP_001345850
	NP_082254
	Wikidata
View/Edit Human	View/Edit Mouse

Para-hydroxybenzoate—polyprenyltransferase, mitochondrial is an enzyme that in humans is encoded by the COQ2 gene.

CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004).[supplied by OMIM]