CORO1A

CORO1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AKF, 2AQ5, 2B4E
Identifiers
Aliases	CORO1A, CLABP, CLIPINA, HCORO1, IMD8, TACO, p57, coronin 1A
External IDs	OMIM: 605000; MGI: 1345961; HomoloGene: 6545; GeneCards: CORO1A; OMA:CORO1A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,189,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,306,959 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; appendix; ; bone marrow; ; bone marrow cells; ; lymph node; ; trabecular bone; ; thymus;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; thymus; ; spleen; ; tibiofemoral joint; ; blood; ; bone marrow; ; right lung lobe; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein C-terminus binding; identical protein binding; phosphatidylinositol 3-kinase binding; protein homodimerization activity; actin monomer binding; myosin heavy chain binding; cytoskeletal protein binding; actin filament binding; actin binding;
Cellular component	phagocytic cup; extracellular exosome; cytoplasm; actin cytoskeleton; cell cortex; nucleus; cell leading edge; axon; lamellipodium; cortical actin cytoskeleton; early endosome; cell-cell junction; membrane; actin filament; phagocytic vesicle membrane; plasma membrane; cytoplasmic vesicle; immunological synapse; cytoskeleton; phagocytic vesicle; cytosol;
Biological process	negative regulation of vesicle fusion; calcium ion transport; homeostasis of number of cells within a tissue; negative regulation of actin nucleation; phagocytosis; response to cytokine; nerve growth factor signaling pathway; T cell homeostasis; positive regulation of cell migration; regulation of actin cytoskeleton organization; positive chemotaxis; actin filament organization; positive regulation of T cell proliferation; cellular response to interleukin-4; natural killer cell degranulation; regulation of release of sequestered calcium ion into cytosol; regulation of actin polymerization or depolymerization; cell-substrate adhesion; regulation of actin filament polymerization; negative regulation of neuron apoptotic process; positive regulation of T cell activation; regulation of cell shape; innate immune response; early endosome to recycling endosome transport; cell migration; actin cytoskeleton organization; uropod organization; immunological synapse formation; leukocyte chemotaxis; phagolysosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	11151
	12721
	ENSG00000102879
	ENSMUSG00000030707
	P31146
	O89053
	NM_001193333; NM_007074
	NM_001301374; NM_009898
	NP_001180262; NP_009005
	NP_001288303; NP_034028
	Wikidata
View/Edit Human	View/Edit Mouse

Coronin-1A is a protein that in humans is encoded by the CORO1A gene. It has been implicated in both T-cell mediated immunity and mitochondrial apoptosis. In a recent genome-wide longevity study, its expression levels were found to be negatively associated both with age at the time of blood sample and the survival time after blood draw.