CORO1C

CORO1C
Identifiers
Aliases	CORO1C, HCRNN4, coronin 1C
External IDs	OMIM: 605269; MGI: 1345964; HomoloGene: 56537; GeneCards: CORO1C; OMA:CORO1C - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	108,731,526 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,046,819 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; tendon of biceps brachii; ; ganglionic eminence; ; synovial joint; ; Achilles tendon; ; stromal cell of endometrium; ; epithelium of colon; ; urethra; ; popliteal artery; ; tibial arteries;
	Top expressed in
	stroma of bone marrow; ; corneal stroma; ; ventricular zone; ; yolk sac; ; somite; ; ileum; ; epiblast; ; intestinal villus; ; ganglionic eminence; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin filament binding; protein binding; actin binding;
Cellular component	cytoplasm; vesicle; cell projection; lateral plasma membrane; membrane; focal adhesion; plasma membrane; flotillin complex; actin cytoskeleton; cytoskeleton; lamellipodium;
Biological process	regulation of protein phosphorylation; negative regulation of protein phosphorylation; positive regulation of lamellipodium morphogenesis; activation of GTPase activity; establishment of protein localization; regulation of epithelial cell migration; neural crest cell migration; negative regulation of protein kinase activity by regulation of protein phosphorylation; phagocytosis; regulation of focal adhesion assembly; regulation of ruffle assembly; negative regulation of substrate adhesion-dependent cell spreading; regulation of fibroblast migration; regulation of substrate adhesion-dependent cell spreading; negative regulation of focal adhesion assembly; negative regulation of epithelial cell migration; actin cytoskeleton organization; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23603
	23790
	ENSG00000110880
	ENSMUSG00000004530
	Q9ULV4
	Q9WUM4
	NM_001105237; NM_001276471; NM_014325
	NM_011779
	NP_001098707; NP_001263400; NP_055140
	NP_035909
	Wikidata
View/Edit Human	View/Edit Mouse

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.