COX14

COX14
Identifiers
Aliases	COX14, C12orf62, COX14 cytochrome c oxidase assembly factor, cytochrome c oxidase assembly factor, PCAG1, cytochrome c oxidase assembly factor MC4DN10
External IDs	OMIM: 614478; MGI: 1913629; HomoloGene: 50025; GeneCards: COX14; OMA:COX14 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	50,120,457 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,627,413 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle of heart; ; left ventricle; ; muscle of thigh; ; right adrenal gland; ; gastrocnemius muscle; ; anterior pituitary; ; left adrenal gland; ; mucosa of transverse colon; ; left adrenal cortex;
	Top expressed in
	embryo; ; blastocyst; ; extraocular muscle; ; digastric muscle; ; myocardium of ventricle; ; temporal muscle; ; morula; ; sternocleidomastoid muscle; ; soleus muscle; ; facial motor nucleus;
	More reference expression data
	n/a
Orthologs
	84987
	66379
	ENSG00000178449
	ENSMUSG00000023020
	Q96I36
	Q8BH51
	NM_001257133; NM_001257134; NM_032901
	NM_183256
	NP_001244062; NP_001244063; NP_116290
	NP_899079
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase assembly factor COX14 is a protein that in humans is encoded by the COX14 gene. This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants.