COX7A1

COX7A1
Identifiers
Aliases	COX7A1, COX7A, COX7AH, COX7AM, cytochrome c oxidase subunit 7A1
External IDs	OMIM: 123995; MGI: 1316714; HomoloGene: 48051; GeneCards: COX7A1; OMA:COX7A1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	36,152,449 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	29,885,503 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; apex of heart; ; myocardium of left ventricle; ; thoracic diaphragm; ; right auricle of heart; ; muscle of thigh; ; biceps brachii; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle;
	Top expressed in
	myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; interventricular septum; ; digastric muscle; ; intercostal muscle; ; right ventricle; ; temporal muscle; ; muscle of thigh; ; sternocleidomastoid muscle; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; cytochrome-c oxidase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; mitochondrial respirasome;
Biological process	generation of precursor metabolites and energy; proton transmembrane transport; electron transport chain; regulation of oxidative phosphorylation; mitochondrial respirasome assembly;
	Sources:Amigo / QuickGO
Orthologs
	1346
	12865
	ENSG00000161281
	ENSMUSG00000074218
	P24310
	P56392
	NM_001864
	NM_009944
	NP_001855
	NP_034074
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.