COX7A2L

COX7A2L
Identifiers
Aliases	COX7A2L, COX7AR, COX7RP, EB1, SIG81, cytochrome c oxidase subunit 7A2 like, SCAFI, SCAF1
External IDs	OMIM: 605771; MGI: 106015; HomoloGene: 3463; GeneCards: COX7A2L; OMA:COX7A2L - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	42,425,088 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	83,824,759 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; right adrenal cortex; ; Achilles tendon; ; left adrenal gland; ; left adrenal cortex; ; islet of Langerhans; ; middle temporal gyrus; ; amniotic fluid; ; secondary oocyte; ; beta cell;
	Top expressed in
	spleen; ; ganglionic eminence; ; uterus; ; bone marrow; ; pancreas; ; ventricular zone; ; thymus; ; islet of Langerhans; ; duodenum; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; cytochrome-c oxidase activity;
Cellular component	mitochondrial inner membrane; membrane; mitochondrial respirasome; nucleolus; mitochondrion;
Biological process	proton transmembrane transport; electron transport chain; regulation of oxidative phosphorylation; mitochondrial respirasome assembly; mitochondrial electron transport, cytochrome c to oxygen;
	Sources:Amigo / QuickGO
Orthologs
	9167
	20463
	ENSG00000115944
	ENSMUSG00000024248
	O14548
	Q61387
	NM_004718; NM_001319036; NM_001319037; NM_001319038; NM_001319040
	NM_001159529; NM_009187
	NP_001305965; NP_001305966; NP_001305967; NP_001305969; NP_004709
	NP_001153001; NP_033213
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.

The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.

This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence.

This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.