CPA4 (gene)

CPA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BO9, 2BOA, 2PCU, 4A94, 4BD9
Identifiers
Aliases	CPA4, CPA3, carboxypeptidase A4
External IDs	OMIM: 607635; MGI: 1919041; HomoloGene: 56753; GeneCards: CPA4; OMA:CPA4 - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,592,417 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; body of pancreas; ; islet of Langerhans; ; right adrenal gland; ; left adrenal gland; ; vagina; ; placenta; ; spleen; ; minor salivary glands; ; spinal cord;
	Top expressed in
	lip; ; esophagus; ; skin of external ear; ; skin of back; ; embryo; ; skin of abdomen; ; ventricular zone; ; umbilical cord; ; morula; ; epidermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity; peptidase activity; zinc ion binding; hydrolase activity; metallopeptidase activity; metal ion binding; metallocarboxypeptidase activity; protein binding;
Cellular component	extracellular region; extracellular space; cellular component;
Biological process	histone acetylation; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	51200
	71791
	n/a
	ENSMUSG00000039070
	Q9UI42
	Q6P8K8
	NM_016352; NM_001163446
	NM_027926
	NP_001156918; NP_057436
	NP_082202
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.