CPEB1

CPEB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M13, 2MKH, 2MKK, 2N1O
Identifiers
Aliases	CPEB1, CEBP, CPE-BP1, CPEB, CPEB-1, hCPEB-1, h-CPEB, cytoplasmic polyadenylation element binding protein 1
External IDs	OMIM: 607342; MGI: 108442; HomoloGene: 7278; GeneCards: CPEB1; OMA:CPEB1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	82,648,861 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	81,105,213 bp
RNA expression pattern
	Top expressed in
	testicle; ; C1 segment; ; pituitary gland; ; anterior pituitary; ; Brodmann area 9; ; right testis; ; corpus callosum; ; superior frontal gyrus; ; left testis; ; substantia nigra;
	Top expressed in
	primary oocyte; ; superior frontal gyrus; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; secondary oocyte; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; triceps brachii muscle; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; mRNA 3'-UTR AU-rich region binding; translation factor activity, RNA binding; RNA binding; nucleic acid binding; ribosome binding; translation repressor activity, mRNA regulatory element binding; mRNA 3'-UTR binding; translation regulator activity; protein binding;
Cellular component	synapse; cell projection; cell junction; neuron projection; messenger ribonucleoprotein complex; postsynaptic density; postsynaptic membrane; membrane; P-body; dendrite; plasma membrane; cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	cellular response to insulin stimulus; regulation of translation; negative regulation of cytoplasmic translation; mRNA processing; cellular response to amino acid stimulus; cellular response to hypoxia; protein biosynthesis; positive regulation of mRNA polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	64506
	12877
	ENSG00000277445; ENSG00000214575
	ENSMUSG00000025586
	Q9BZB8
	P70166
NM_030594; NM_001079533; NM_001079534; NM_001079535; NM_001288819;
	NM_001288820
	NM_001252525; NM_001252526; NM_007755; NM_001357107
NP_001073001; NP_001073002; NP_001073003; NP_001275748; NP_001275749;
	NP_085097; NP_001352169; NP_001352170; NP_001352171; NP_001352172; NP_001352173; NP_001352174; NP_001352175; NP_001352176; NP_001352177; NP_001352178; NP_001352179
	NP_001239454; NP_001239455; NP_031781; NP_001344036
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.

This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3′ UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.