CPSF3

CPSF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I7T, 2I7V
Identifiers
Aliases	CPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3
External IDs	OMIM: 606029; MGI: 1859328; HomoloGene: 6499; GeneCards: CPSF3; OMA:CPSF3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	9,473,101 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	21,365,057 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; left testis; ; right testis; ; endothelial cell; ; tendon of biceps brachii; ; sperm; ; monocyte; ; stromal cell of endometrium; ; islet of Langerhans;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; ureter; ; internal carotid artery; ; condyle; ; fossa; ; vas deferens; ; Epithelium of choroid plexus; ; external carotid artery; ; endothelial cell of lymphatic vessel;
	More reference expression data
	n/a
Gene ontology
Molecular function	5'-3' exonuclease activity; metal ion binding; endoribonuclease activity; protein binding; RNA binding; nuclease activity; endonuclease activity; hydrolase activity;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA 3'-end processing by stem-loop binding and cleavage; mRNA processing; mRNA export from nucleus; mRNA polyadenylation; mRNA cleavage; mRNA 3'-end processing; RNA phosphodiester bond hydrolysis, endonucleolytic; sno(s)RNA 3'-end processing; snoRNA splicing; pre-mRNA cleavage required for polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	51692
	54451
	ENSG00000119203
	ENSMUSG00000054309
	Q9UKF6
	Q9QXK7
	NM_016207; NM_001321833; NM_001321834; NM_001321835; NM_001321836
	NM_018813; NM_001364372; NM_001364373
	NP_001308762; NP_001308763; NP_001308764; NP_001308765; NP_057291
	NP_061283; NP_001351301; NP_001351302
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.