CPZ (gene)

CPZ
Identifiers
Aliases	CPZ, carboxypeptidase Z
External IDs	OMIM: 603105; MGI: 88487; HomoloGene: 2709; GeneCards: CPZ; OMA:CPZ - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	8,619,759 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,683,042 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; placenta; ; gallbladder; ; canal of the cervix; ; ectocervix; ; stromal cell of endometrium; ; vagina; ; fallopian tube; ; right uterine tube;
	Top expressed in
	body of femur; ; calvaria; ; molar; ; skin of back; ; lens; ; urethra; ; vestibular sensory epithelium; ; cornea; ; skin of abdomen; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity; zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metallocarboxypeptidase activity; serine-type carboxypeptidase activity;
Cellular component	extracellular region; extracellular space;
Biological process	protein processing; Wnt signaling pathway; proteolysis; peptide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8532
	242939
	ENSG00000109625
	ENSMUSG00000036596
	Q66K79
	Q8R4V4
	NM_003652; NM_001014447; NM_001014448
	NM_153107
	NP_001014447; NP_001014448; NP_003643
	NP_694747
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.