CREB5

CREB5
Identifiers
Aliases	CREB5, CRE-BPA, CREB-5, cAMP responsive element binding protein 5, CREBPA
External IDs	OMIM: 618262; MGI: 2443973; HomoloGene: 18215; GeneCards: CREB5; OMA:CREB5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	28,825,894 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	53,677,361 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; ventricular zone; ; blood; ; corpus callosum; ; tendon of biceps brachii; ; monocyte; ; inferior ganglion of vagus nerve; ; synovial membrane; ; internal globus pallidus; ; cartilage tissue;
	Top expressed in
	hand; ; ascending aorta; ; aortic valve; ; foot; ; lumbar subsegment of spinal cord; ; hair follicle; ; ventricular zone; ; genital tubercle; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	extracellular exosome; nucleus;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9586
	231991
	ENSG00000146592
	ENSMUSG00000053007
	Q02930
	Q8K1L0
	NM_001011666; NM_004904; NM_182898; NM_182899
	NM_172728; NM_001327821
	NP_001011666; NP_004895; NP_878901; NP_878902
	NP_001314750; NP_766316
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.