CREG1

CREG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XHN
Identifiers
Aliases	CREG1, CREG, cellular repressor of E1A stimulated genes 1
External IDs	OMIM: 618055; MGI: 1344382; HomoloGene: 31199; GeneCards: CREG1; OMA:CREG1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,553,805 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,602,877 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; hair follicle; ; vulva; ; skin of arm; ; gallbladder; ; parotid gland; ; lower lobe of lung; ; skin of hip; ; gingival epithelium; ; trabecular bone;
	Top expressed in
	blood; ; stroma of bone marrow; ; left lobe of liver; ; epithelium of stomach; ; fetal liver hematopoietic progenitor cell; ; transitional epithelium of urinary bladder; ; saccule; ; otic placode; ; lacrimal gland; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; transcription corepressor activity;
Cellular component	extracellular exosome; transcription regulator complex; extracellular region; extracellular space; azurophil granule lumen;
Biological process	regulation of transcription by RNA polymerase II; multicellular organism development; regulation of growth; cell population proliferation; regulation of transcription, DNA-templated; negative regulation of nucleic acid-templated transcription; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8804
	433375
	ENSG00000143162
	ENSMUSG00000040713
	O75629
	O88668
	NM_003851
	NM_011804
	NP_003842
	NP_035934
	Wikidata
View/Edit Human	View/Edit Mouse

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene.

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.