CRHBP

CRHBP
Identifiers
Aliases	CRHBP, CRF-BP, CRFBP, corticotropin releasing hormone binding protein
External IDs	OMIM: 122559; MGI: 88497; HomoloGene: 1418; GeneCards: CRHBP; OMA:CRHBP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	76,981,158 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,581,432 bp
RNA expression pattern
	Top expressed in
	gonad; ; spleen; ; liver; ; right lobe of liver; ; prefrontal cortex; ; testicle; ; left adrenal cortex; ; right adrenal cortex; ; human kidney; ; Hypothalamus;
	Top expressed in
	vestibular membrane of cochlear duct; ; ciliary body; ; iris; ; lens; ; lumbar subsegment of spinal cord; ; hippocampus proper; ; Region I of hippocampus proper; ; visual cortex; ; vestibular sensory epithelium; ; Amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	corticotropin-releasing hormone binding; protein binding; peptide binding;
Cellular component	Golgi apparatus; secretory granule; endoplasmic reticulum; perikaryon; axon terminus; dense core granule; dendrite; varicosity; secondary lysosome; multivesicular body; microtubule; extracellular region; extracellular space; intracellular anatomical structure; nucleus;
Biological process	negative regulation of corticotropin secretion; female pregnancy; cellular response to tumor necrosis factor; regulation of corticotropin secretion; cellular response to estrogen stimulus; hormone-mediated signaling pathway; behavioral response to ethanol; learning or memory; regulated exocytosis; inflammatory response; signal transduction; cellular response to potassium ion; cellular response to cocaine; negative regulation of corticotropin-releasing hormone receptor activity; synaptic transmission, dopaminergic; maternal aggressive behavior; hormone metabolic process; cellular response to calcium ion; cellular response to cAMP; cellular response to estradiol stimulus; cellular response to gonadotropin-releasing hormone; regulation of NMDA receptor activity; regulation of cellular response to stress;
	Sources:Amigo / QuickGO
Orthologs
	1393
	12919
	ENSG00000145708
	ENSMUSG00000021680
	P24387
	Q60571
	NM_001882
	NM_198408
	NP_001873
	NP_940800
	Wikidata
View/Edit Human	View/Edit Mouse

Corticotropin-releasing factor-binding protein is a protein that in humans is encoded by the CRHBP gene. It belongs to corticotropin-releasing hormone binding protein family.

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.