CRKL

CRKL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BZX, 2BZY, 2EO3, 2LQN, 2LQW
Identifiers
Aliases	CRKL, CRK like proto-oncogene, adaptor protein
External IDs	OMIM: 602007; MGI: 104686; HomoloGene: 38021; GeneCards: CRKL; OMA:CRKL - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,953,747 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,305,298 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; Brodmann area 10; ; Skeletal muscle tissue of rectus abdominis; ; paraflocculus of cerebellum; ; internal globus pallidus; ; embryo; ; ganglionic eminence; ; amniotic fluid; ; cerebellar vermis;
	Top expressed in
	Rostral migratory stream; ; tail of embryo; ; medial ganglionic eminence; ; tibiofemoral joint; ; internal carotid artery; ; genital tubercle; ; vestibular membrane of cochlear duct; ; zygote; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; RNA binding; cadherin binding; phosphotyrosine residue binding; identical protein binding;
Cellular component	cytoplasm; cytosol; endosome; extracellular exosome; nucleoplasm; neuromuscular junction; protein-containing complex; synapse; extrinsic component of postsynaptic membrane;
Biological process	animal organ morphogenesis; pattern specification process; JNK cascade; heart development; Ras protein signal transduction; intracellular signal transduction; blood vessel development; parathyroid gland development; anterior/posterior pattern specification; positive regulation of cell population proliferation; thymus development; positive regulation of substrate adhesion-dependent cell spreading; regulation of cell growth; urogenital system development; neuron migration; B cell apoptotic process; negative regulation of protein phosphorylation; positive regulation of protein phosphorylation; regulation of leukocyte migration; outflow tract morphogenesis; lipid metabolism; spermatogenesis; single fertilization; synapse assembly; fibroblast growth factor receptor signaling pathway; male gonad development; regulation of gene expression; negative regulation of gene expression; dendrite development; cytokine-mediated signaling pathway; hippocampus development; cerebral cortex development; establishment of cell polarity; regulation of cell adhesion mediated by integrin; helper T cell diapedesis; reelin-mediated signaling pathway; positive regulation of Ras protein signal transduction; retinoic acid receptor signaling pathway; regulation of dendrite development; T cell receptor signaling pathway; cell chemotaxis; pharynx development; positive regulation of ERK1 and ERK2 cascade; cellular response to transforming growth factor beta stimulus; response to fibroblast growth factor; endothelin receptor signaling pathway; activation of GTPase activity; acetylcholine receptor signaling pathway; cerebellar neuron development; cellular response to interleukin-7; positive regulation of glial cell migration; regulation of skeletal muscle acetylcholine-gated channel clustering; cranial skeletal system development; regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	1399
	12929
	ENSG00000099942
	ENSMUSG00000006134
	P46109
	P47941
	NM_005207
	NM_001277231; NM_007764
	NP_005198
	NP_001264160; NP_031790
	Wikidata
View/Edit Human	View/Edit Mouse

Crk-like protein is a protein that in humans is encoded by the CRKL gene.