CRMP1

CRMP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B3Z
Identifiers
Aliases	CRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3, collapsin response mediator protein 1
External IDs	OMIM: 602462; MGI: 107793; HomoloGene: 20347; GeneCards: CRMP1; OMA:CRMP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	5,893,086 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	37,449,477 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; lateral nuclear group of thalamus; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; right frontal lobe; ; paraflocculus of cerebellum; ; anterior pituitary;
	Top expressed in
	ganglionic eminence; ; superior cervical ganglion; ; barrel cortex; ; olfactory bulb; ; entorhinal cortex; ; CA3 field; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; medial ganglionic eminence; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; filamin binding;
Cellular component	spindle; cytoskeleton; microtubule organizing center; cytoplasm; cytosol; midbody; centrosome; nucleus;
Biological process	neuron development; nucleobase-containing compound metabolic process; microtubule cytoskeleton organization; nervous system development; axon guidance; negative regulation of actin filament binding; negative regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	1400
	12933
	ENSG00000072832
	ENSMUSG00000029121
	Q14194
	P97427
	NM_001313; NM_001014809; NM_001288661; NM_001288662
	NM_001136058; NM_007765
	NP_001014809; NP_001275590; NP_001275591; NP_001304
	NP_001129530; NP_031791
	Wikidata
View/Edit Human	View/Edit Mouse

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.

CRMP1 mediates reelin signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.

CRMP1 gene overlaps with another gene called EVC.