CRTC1

CRTC1
Identifiers
Aliases	CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
External IDs	OMIM: 607536; MGI: 2142523; HomoloGene: 41607; GeneCards: CRTC1; OMA:CRTC1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,782,333 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,892,229 bp
RNA expression pattern
	Top expressed in
	beta cell; ; paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; Brodmann area 10; ; middle frontal gyrus; ; frontal pole; ; cerebellar vermis; ; right frontal lobe; ; nucleus accumbens; ; cingulate gyrus;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; genital tubercle; ; lumbar subsegment of spinal cord; ; tail of embryo; ; neural layer of retina; ; cerebellar cortex; ; hippocampus proper; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cAMP response element binding protein binding;
Cellular component	soma; plasma membrane; dendrite; synapse; nucleus; nucleoplasm; cytoplasm; cytosol; nuclear body; postsynaptic density; glutamatergic synapse;
Biological process	positive regulation of CREB transcription factor activity; viral process; positive regulation of dendrite development; memory; entrainment of circadian clock by photoperiod; protein homotetramerization; positive regulation of long-term synaptic potentiation; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; rhythmic process; regulation of transcription, DNA-templated; energy homeostasis; negative regulation of membrane hyperpolarization; postsynapse to nucleus signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23373
	382056
	ENSG00000105662
	ENSMUSG00000003575
	Q6UUV9
	Q68ED7
	NM_001098482; NM_015321; NM_025021
	NM_001004062
	NP_001091952; NP_056136
NP_001004062; NP_001391344; NP_001391345; NP_001391346; NP_001391347;
	NP_001391348; NP_001391349; NP_001391350; NP_001391351; NP_001391352; NP_001391353; NP_001391354; NP_001391355; NP_001391356; NP_001391357; NP_001391358; NP_001391359
	Wikidata
View/Edit Human	View/Edit Mouse

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands and various regions of the adult central nervous system.